DR. CHARLES MOBBS
Dr. Mobbs is an award-winning scientist, mentor and professor of Neuroscience, Endocrinology, Geriatrics, Pharmacology and Therapeutics Discovery at the Mount Sinai School of Medicine, in New York City.
He holds a B.Sc. in Life Sciences from the Massachusetts Institute of Technology, PhD in Molecular Biology from the University of Southern California and a Post-Doc in Molecular Neuroscience from the Rockefeller University.
The main focus of his laboratory is to elucidate the mechanisms linking lifespan to age-related diseases, particularly mechanisms mediating protective effects of dietary restriction to delay almost all age-related pathologies, natural or engineered.
Positions, Scientific Appointments and Honors
2019: Professor, Pharmacology and Therapeutics Discovery
2011: Professor, Medicine/Endocrinology
2007: Professor, Neuroscience and Geriatrics
1997: Associate Professor, Neurobiology and Geriatrics, Mt. Sinai School of Medicine
1992: Assistant Professor, Neurobiology and Geriatrics, Mt. Sinai School of Medicine
1988-1992: Assistant Professor, Rockefeller University
Awards
Winner of 2010 Outstanding Mentorship Award at Mt. Sinai School of Medicine
Winner of 2012 Glenn Award for Research in Biological Mechanisms of Aging
Additional Contributions
Other Experience and Professional Memberships:
2021: Special Interest Study Section ZDK1 GRB-B (M2) RFA-DK-20-021 (Diabetes & COVID-19)
2020: Chair, Special Emphasis Panel ZRG1 CB-D (02), NIA (aging, lifespan, neuro-degeneration)
2015-2018: American Diabetes Association Scientific Review Committee
2009-2020: Chair, Interventions Testing Program Access Committee, NIA
2008-2022: Special Emphasis Study Sections (particularly involving metabolism)
2006-2009: Endocrine Society Steering Committee
2005-2009: Interventions Testing Program Access Committee, NIA
2005-2009: Editorial Board, Endocrinology
2005-2008: IPOD Study Section
2004-2007: American Diabetes Association Scientific Review Panel
Additional Service to Mt. Sinai
2022: FCOI Conflict Committee
2021 - Present: FBI Speaker Committee
2012 - Present: Faculty Representative to National Federal l Demonstration Project
Interview at Mount Sinai
https://ip.mountsinai.org/blog/meet-charles-mobbs-phd-of-team-gilga-med-a-mount-sinai-pitch-challenge-2021-contestant/
Publication Topics
gene memory - estrogen (menopause) and glucose (diabetes and aging)
metabolic mapping to assess mechanisms mediating hypothalamic sensing of glucose
critical role of hypothalamic POMC in regulating metabolism and aging
role of Cbp in mediating protective effects of dietary restriction on lifespan, Alzheimer’s and other diseases of aging
ketogenic diet: metabolic mechanisms mediating reversal of diabetic complications
Complete List of Published Works:
https://www.ncbi.nlm.nih.gov/myncbi/1xA0OIKs1Ch5J/bibliography/public/
Articles in Press or Preparation
Litke, R., and Mobbs CV. Drugs, diets, and genes that increase lifespan and delay age-related diseases: Role of nutrient-sensing neurons and Creb-binding protein. Pharm. Biochem. Behavor (in press).
Litke, R., Vicari, J., Gonzalez, D., Huang, B.T., Jin, J. Kellner, C., and Mobbs, C.V. A novel compound which is highly protective in animal models of Alzheimer’s Disease and stroke, inhibits microglial cytokine secretion, is highly concentrated in brain after oral delivery, and increases lifespan with no evidence of toxicity (in prep)
Vicari, J., Litke, R., and Mobbs, C.V. Structure-activity studies to discover novel compounds which inhibit mouse and human microglial and macrophage secretion of TNF-alpha and IL-6 (in prep).
Huang, B.T., Litke, R. and Mobbs, C.V. Structure-activity studies to discover novel compounds which delay impairments in a C. elegans model of Alzheimer’s Disease (in prep).
Sharma, O. and Mobbs, C.V. Inhibition of genes implicated in lifespan also delays impairments in a C. elegans model of Alzheimer’s Disease (in prep)
Gonzalez, D., and Mobbs, C.V. Novel compounds that are protective in animal models of Alzheimer’s Disease and stroke are also protective in an animal model of Huntington’s Disease (in prep.)
Cox, S., Gonzalez, D., and Mobbs, C.V. Effects of Phenothiazines on Microglia TNF-a and IL-6 Secretion: Relevance to in Alzheimer’s Disease (in prep)
Clarke, B., Gonzalez, D., Ehrlich, M., and Mobbs, C.V. Compounds implicated in mediating protective effects of TyroBP ablation in Alzheimer’s Disease delay impairments in a C. elegans model of Alzheimer’s Disease (in prep)
Ma, G., Shapiro, L, and Mobbs, C.V. Molecular mechanisms mediating protective effects of phenothiazines in animal models of Alzheimer’s Disease. (in prep)
Shackleton, B., Ehrlich, M, Zhang, B. and Mobbs, C.V. Inhibition of genes implicated in Alzheimer’s Disease gene resilience accelerate impairments in a C. elegans model of Alzheimer’s Disease (in prep).